Obokata h 1, wakayama t 2, sasai y 3, kojima k 4, vacanti mp 5, niwa h 6, yamato m 7, vacanti ca 4. Here we report a unique cellular reprogramming phenomenon. Stimulus triggered fate conversion of somatic cells into. Direct reprogramming of somatic cells into induced neurons duration. Pdf stimulustriggered fate conversion of somatic cells. Stimulustriggered fate conversion of somatic cells into. Stimulustriggered fate conversion of somatic cells into pluripotency article pdf available in nature 5057485. The use of human genome editing to make edits in somatic cells for purposes of. Essential technical tips for stap cell conversion culture from. Stimulustriggered fate conversion of somatic cells into pluripotency. Stimulustriggered fate conversion of somatic cells into pluripotency, nature on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. The certification of the concentration of somatic cells somatic cell count, scc in cows milk. The certification of the concentration of somatic cells somatic cell.
In stap, strong external stimuli such as a transient lowph stressor reprogrammed mammalian somatic cells, resulting in the generation of pluripotent cells. Stimulustriggered fate conversion of somatic cells i. Vacanti1 here we report a unique cellular reprogramming phenomenon, called stimulustriggered acquisition of pluripotency. Stimulustriggered fate conversion of somatic cells into pluripotency in chronic wounds in human beings.
Through realtime imaging of stap cells derived from purified lymphocytes, as well as gene rearrangement analysis, we found that committed somatic cells give rise to stap cells by. Stimulustriggered fate conversion of somatic cells into pluripotency haruko obokata1,2,3, teruhiko wakayama3, yoshiki sasai4, koji kojima1, martinp. Authors yoshiki sasai pdf 9kb the webpage will open in a new tab. The human body originates from a totipotent stem cell, the zygote. Haruko obokata, teruhiko wakayama, yoshiki sasai, koji kojima, martin p. Stimulustriggered acquisition of pluripotency \stap is a cellular. Dedifferentiation of somatic cells to a pluripotent state intechopen.
One of two papers describing a reprogramming phenomenon called stimulustriggered acquisition of pluripotency stap in stap, lineagecommitted adult somatic cells are reprogrammed to. It was not clear why ordinary cells do not convert into stem cells when. Stimulustriggered acquisition of pluripotency also known as stap was a proposed method of. Stimulustriggered acquisition of pluripotency wikipedia.
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